The significant differences in C-reactive protein, fibrinogen, total cholesterol, and triglycerides according to the level of obesity defined by different anthropometric parameters suggest that interrelations between obesity, inflammation, haemostatic disturbance, and other risk factors may possibly play an important additional role in endothelial dysfunction involved in the pathogenesis of diabetic retinopathy. This evidence concerns the gene CRP and obesity due to melanocortin 4 receptor deficiency.