Also in a mouse model of X-ALD, Yanagiasawa and coworkers showed that peritoneal macrophages from Abcd1-deficient mice secreted significantly elevated levels of TNF-α, IL-6 and IL-12p70 upon stimulation by LPS and interferon-γ (IFN-γ) compared with wild-type mice (26). This evidence concerns the gene TNF and X-linked adrenoleukodystrophy.