CD8A and neoplasm: Among these cytokines, IFNγ has been recognized as its pivotal role in anti-tumor immunity by enhancing tumor immunogenicity for antigen presentation [2, 3], inducing apoptosis in tumor cells [4], promoting T helper 1 (Th1) differentiation [5, 6] and augmenting cytotoxicity of CD8+ cytotoxic T lymphocytes (CTLs) [7].