TNFSF10 and cancer: HeLa cells are sensitive to higher concentrations of TRAIL; however, many other cancer cell lines and most primary cancer cells are TRAIL resistant.7 Therefore, we next tested whether the exceptionally potent TRAIL sensitization exerted by PIK-75 in HeLa cells would translate into sensitization of the highly TRAIL resistant non-small cell lung cancer (NSCLC) cell line A549.