SLC22A12 and gout: We present several important findings: 1) novel association of rs17299124 upstream of SLC22A11 with gout in Polynesians and not Caucasians, which is driven by a protective effect; 2) evidence for association of the SLC22A11 SNP rs2078267 with gout in Polynesians with the previously reported association in European Caucasians not replicated; and 3) the SLC22A12 analysis was the first report of nominally significant association with gout in European Caucasians, with the haplotype analysis suggesting multiple alleles conferring risk at SLC22A12 in an ancestry-specific manner.