MMP2 and Hepatic fibrosis: Interestingly, they include several important players in ECM remodeling in liver fibrosis, such as connective tissue growth factor [10,11], transforming growth factor-β [12], which is active in ECM deposition, and matrix metalloproteinases 2, 9, and 12 (MMP-2, MMP-9 and MMP-12) and their inhibitor, tissue inhibitor of metalloproteinase type 1 (TIMP-1), which is involved in altered matrix degradation [13,14].