SLC3A2 and neoplasm: When each stable cell lines were transplanted into athymic nude mice, a significantly enhanced tumor growth was only observed in the CD98hc over-expressing tumor transplants on day 8 (135 ± 21 mg in highCD98hc/Caki2 vs. 12 ± 9 mg in lowC98hc/Caki2 tumors, n = 5 mice/group) (Figure 1B).