SLC3A2 and neoplasm: By studding either highCD98hc/Caki2 cells, lowCD98hc/Caki2 cells, silCD98hc/Caki2 cells, trunsilCD98hc/Caki2 or poinsilCD98hc/Caki2 cells for tumor cell proliferation, we found that only the wild-type CD98hc reconstituting mutant silCD98hc could completely rescue the high proliferative phenotype (93 ± 4% after 24 h and 98 ± 2% after 48 h of high CD98hc Caki2, p < 0.001).