Thus, we generated a stable low CD98hc expressing ccRCC cell line (lowCD98hc/CaKi2) as well as a control high CD98hc expressing ccRCC cell line (highCD98hc/CaKi2) by the use of a CD98hc mRNA targeting shRNA and scrambled control bearing lentiviral construct, respectively. This evidence concerns the gene SLC3A2 and nonpapillary renal cell carcinoma.