Furthermore, ccRCC cell transmigration was affected by CD98hc expression, because the 4 hours transmigration rate of lowCD98hc/CaKi2 cells was decreased to 19 ± 2%, 24 ± 7% after 12 hours and 41 ± 4% after 24 hours when compared to highCD98hc/Caki2 cells (Figure 3C). Here, SLC3A2 is linked to nonpapillary renal cell carcinoma.