For age-adjusted risk models, elevations in prostate cancer susceptibility were observed among carriers of IL1R2 rs1188687 7AA (OR = 1.92; 95%CI = 1.11, 3.32), IL8RB rs11574752 GA + AA (OR = 38.40; 95%CI = 3.86, 382.8), TNF rs1800629 GA + AA (OR = 1.53; 95%CI = 1.06, 2.20), and TNF rs673 GA (OR = 1.50; 95%CI = 1.04, 2.16) genotypes with risk estimates ranging from 1.50-38.4. The gene discussed is TNF; the disease is Familial prostate cancer.