Other investigations on prostate cancer found that pomegranate polyphenols, ellagitannin-rich extract (PE) made from fruit skins standardized to ellagitannins, can restraint prostate cancer cell caused by chronic inflammation via suppressing NF-κB pathway, which is well-established signaling pathway mediating the inflammation relevant to cancer[14]. This evidence concerns the gene NFKB1 and prostate carcinoma.