BCL2 and Familial prostate cancer: In resemblance to our findings, the examination of PFE (acetone extract) reported by Malik et al. (2005) found that PFE treatment to prostate cancer and lung cancer cells could induce G1 phase arrest and provoke prostate cancer cell apoptosis by dys-regulation of both cyclins and CDKs and down-regulation of anti-apoptotic Bcl-XL and Bcl-2[13].