Nearly all cases of Ewing’s sarcoma show the presence of the chimeric transcription factor EWS/ETS which causes upregulation of PDGF-C; treatment of a cell line from a Ewing’s sarcoma with a PDGFR kinase inhibitor was shown to inhibit its anchorage-independent growth[144]. The gene discussed is PDGFC; the disease is Ewing sarcoma.