WRN hypermethylation in epithelial tumors was most prevalent in colorectal cancer (37.9%, 69/182), followed by non-small cell lung (37.5%, 21 /56), gastric (25%, 10/38), prostate (20%, 4/20), breast (17.2%, 10/58), and thyroid (12.5%, 4/32) tumors [4]. This evidence concerns the gene WRN and colorectal cancer.