TNF and chronic recurrent multifocal osteomyelitis: Unlike most human CRMO patients, CMO and lupo mice exhibit additional signs of systemic inflammation, including hepatosplenomegaly, extramedullary hematopoiesis, and elevated serum inflammatory parameters (MIP-1a, RANKL, both osteoclastogenic factors, IL-1α, IL-1β, TNF-α, and IL-6) [54,55].