Polymorphisms in genes that co-segregate with related inflammatory conditions were not present in CNO/CRMO (PSTPIP1, PSTPIP2, LPIN2, IL1RN, CARD15), indicating that CRMO and those inflammatory disorders may be related and share key symptoms but are still distinct from one another [38-40]. Here, PSTPIP2 is linked to chronic recurrent multifocal osteomyelitis.