Unlike most human CRMO patients, CMO and lupo mice exhibit additional signs of systemic inflammation, including hepatosplenomegaly, extramedullary hematopoiesis, and elevated serum inflammatory parameters (MIP-1a, RANKL, both osteoclastogenic factors, IL-1α, IL-1β, TNF-α, and IL-6) [54,55]. This evidence concerns the gene IL1B and chronic recurrent multifocal osteomyelitis.