BMI1 and cancer: Melanoma /miR-200c is commonly found to be downregulated in malignant melanoma that possess self-renewal cancer stem-cell like property and are more invasive. The prominent miR-200c downregulation is accompanied by Bmi-1 overexpression, which was found to cause loss of E-cadherin (thereby EMT) and overexpression of MDR transporters (including ABCG2, ABCG5 and MDR).