To identify the Fc galactosylation and sialylation of RhD-specific IgG Abs in a commercially available polyclonal anti-RhD IgG product, we purified RhD-specific IgG Abs from the approved product Rhophylac® (CSL Behring, King of Prussia, PA, USA) and analyzed the Abs’ Fc glycosylation. Here, DDX41 is linked to rheumatic heart disease.