Based on the antiviral and immunomodulatory effect of HBD-3 and LL-37, as well as the angiogenic role of LL-3725, this study was carried out to assess the expression of the two main antimicrobial peptides (HBD-3 and LL-37) in skin lesions of KS in comparison to normal skin from healthy subjects. Here, CAMP is linked to Kaposi's sarcoma.