These changes in hepatic metabolites were associated with hepatic damage (ATL and AST) and the induction of multiple gene expression markers of NASH, including MUFA synthesis (SCD1), inflammation (MCP1, CD68, TLR4), oxidative stress (HMOX-1 & NOX2) and fibrosis (proCOL1A1). The gene discussed is CYBB; the disease is metabolic dysfunction-associated steatohepatitis.