These changes in hepatic metabolites were associated with hepatic damage (ATL and AST) and the induction of multiple gene expression markers of NASH, including MUFA synthesis (SCD1), inflammation (MCP1, CD68, TLR4), oxidative stress (HMOX-1 & NOX2) and fibrosis (proCOL1A1). Here, HMOX1 is linked to metabolic dysfunction-associated steatohepatitis.