Dietary DHA>EPA attenuates NASH progression by regulating multiple processes, including membrane sphingomyelin and phosphoglycerolipid content, nuclear content of key transcription factors (NFκB, SREBP1, NRF2 and others), expression of genes involved in lipid metabolism, inflammation, oxidative stress, fibrosis, improved glucose metabolism, and detoxification of methylglyoxal. This evidence concerns the gene SREBF1 and metabolic dysfunction-associated steatohepatitis.