LDLR-/- mice fed the WD + O for 16 weeks developed a robust NASH phenotype characterized by hepatosteatosis, hepatic damage (plasma ALT & AST), inflammation (MCP1), oxidative stress (Hmox-1 and NOX2) and fibrosis (ProCol1A1). The gene discussed is CYBB; the disease is metabolic dysfunction-associated steatohepatitis.