It is known that autophagy process is tightly regulated by a cascade of kinases [21] and accumulating evidences indicated that autophagy in various cancer cells could be induced through the activation of ERK1/2 by natural compounds, including AAI [22], daunorubicin [29], curcumin [30] and triterpenoid B-group soyasaponins [31]. Here, MAPK3 is linked to cancer.