Although IL-1-induce MMPs are involved in the breakdown of ECM in disease processes, such as arthritis and tumor metastasis [11], [41]–[43], there is no MMP-3 mRNA and MMP-3 under normal physiological conditions because of the absence of the required cytokines to stimulate production of this protein, as shown in Figure 1. Here, MMP3 is linked to neoplasm.