Patients who healed their ulcers also had lower serum CRP at visit 1 (Figure 3A, p<0.05), lower interleukin-1 alpha (IL-1α) at visit 1 (Figure 3B, p<0.05) and visit 4 (p<0.05), lower Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) at visit 1 (Figure 3C, p<0.05) and marginally lower GM-CSF at visit 4 (p=0.072). This evidence concerns the gene IL1A and ulcer disease.