APOE and aneurysm: Recent studies reported that Notch1 inhibition reduced infiltration of CD3+ T lymphocytes at the site of aneurysm tissues, but no effect of Notch on CD4+ or CD8+ T cell differentiation were observed in the aneurysmal aorta or spleen between Apo E−/− and Notch1+/−ApoE-/-groups after Ang II treatment [3,28].