Consistent with these results, our data demonstrated that Ang II stimulated a dramatic increase in neovascularization, the mRNA expression of VEGF and HIF, and the levels of ERK and AKT phosphorylation in the aortas of AAA in Apo E-/- mice, whereas these effects Ang II on the expression of VEGF and HIF, and the levels of ERK phosphorylation were markedly decreased in the aortas of Apo E-/- mice treated with DBZ. Here, APOE is linked to triple-A syndrome.