To investigate whether obesity modulates the expression KLFs in adipose tissue, the mRNA levels of KLF3, KLF9, KLF10, KLF13 and KLF15 were evaluated in epididymal adipose tissue of diet-induced obese (DIO) and control lean mice by RT-PCR methods. This evidence concerns the gene KLF10 and obesity due to melanocortin 4 receptor deficiency.