In contrast Kumarakulasingham et al. reported significant correlations for CYP1B1 but not for CYP1A1 between the expression of this protein in the primary tumor and the expression in the secondary metastatic tumor in 264 subjects with primary colon cancer and 91 subjects with lymph node metastasis [36]. This evidence concerns the gene CYP1B1 and metastatic neoplasm.