CYP1B1 and colonic neoplasm: Gibson and coworkers reported in 2003 that CYP1B1 protein expression does not possess a direct role in tumor invasion as the level of CYP1B1 expression in stage 1 (pT1 and pT2) was not significantly different than that of stage 2 colon tumors (pT3 and pT4) in a sample size of 61 colon tumors [37].