During tumour growth, tumour cells secrete pro-angiogenic proteins such as vascular endothelial growth factor (VEGF), angiopoietins (Ang), platelet-derived growth factor (PDGF) and matrix metalloproteinases (MMP) to stimulate endothelial cell proliferation, migration and vascular tube formation [3], [4]. This evidence concerns the gene VEGFA and neoplasm.