ACTA1 and hydrops fetalis: In our study, since the development of oral medications to help prevent liver injury is desirable[40], orally treatment with HF significantly improved liver histology(Figure 4B) and declined the high values of Collagen α1(I) protein(Figure 5A), and we found the decline in collagen deposition was accompanied by a reduction in numbers α-SMA positive cells(Figure 5B), pointing to the fact that HF may affect collagen levels by more than one mechanism.