TFF3 and metastatic malignant neoplasm in the lymph nodes: Multivariate analysis showed that lymph node metastasis and the expression of TFF3 and TACC1 in tumor epithelial cells were independent prognostic factors for overall survival (Table 4), and that the hazard ratio (HR) of tumor-related death increased by 3.409 fold in FF3 group (P<0.001; 95% CI 2.387–8.143).