NPM, TFF3 and TACC1 expressions were significantly higher in patients with poor differentiated histologic type GC than those in patients with well differentiated histologic type GC (NPM, 0.88 vs. 0.12; TFF3, 0.90 vs. 0.10; TACC1, 0.90 vs. 0.10; P<0.05). This evidence concerns the gene TFF3 and gastric cancer.