Although the functional relevance of rs666478 associating with eGFR needs to be explored, genetic variants located about 5 Mb upstream of TEK on cyclin-dependent kinase inhibitor (CDKN) 2A, 2B genes have been previously associated with type 2 diabetes mellitus [37] and coronary heart disease [38]. This evidence concerns the gene CDKN3 and coronary artery disorder.