Furthermore, genes located near the eGFR linkage markers on 10p12, including calcium channel, voltage-dependent, beta 2 subunit (CACNB2), ARL5B ADP-ribosylation factor-like 5B (ARL5), and nebulette (NEBL), were previously associated with eGFR-related traits such as blood pressure and hypertension [33], sudden cardiac arrest and diabetic retinopathy [34]. The gene discussed is CACNB2; the disease is diabetic retinopathy.