Although the functional mechanism by which these two variants residing within the PDIA6 and regulating renal function needs to be examined, genetic variants located about 7 Mb upstream of PDIA6 on the SRY (sex determining region Y)-box 11 (SOX11) gene were previously associated with T2DM and CKD in Europeans [17]. Here, SOX11 is linked to type 2 diabetes mellitus.