It was reported that this intermediate CD14+CD16+ subset (same subset is also referred to as CD14++CD16+ or CD14highCD16+) was expanded in patients with allergies [16] and asthma [17] and expressed a number of M2 surface markers such as CD163, CX3CR1, IL-4R, TGF-β1 and IL-10 [17], [34]–[36]. This evidence concerns the gene CX3CR1 and allergic disease.