CCND1 and Familial prostate cancer: It has been suggested, therefore, that loss of α-catenin leads to the loss of e-cadherin function leading to a poorer prognosis [18], whereas, repletion of α-catenin in α-catenin null prostate cancer cells has been reported to increase adherens junction formation and reduced transcriptional activity of β-catenin, cyclin D1 levels and cell proliferation [26].