We further showed inflammasome activation in microglia increases oAβ-induced neuronal cell death, which is ameliorated by the inhibition of caspase-1 and IL-1β. Consistent with this observation, genetic deletion of NLRP3 in mice expressing mutant human APP/PS1, an animal model of AD, deceases their disease burden.24 Here, CASP1 is linked to Alzheimer disease.