Using a GeneChip microarray, we found that CST1 was significantly upregulated in CRC tissues, as previously reported in gastric cancer.28 The mRNA transcript of CST1 was highly elevated in CRC tissues (n=66, P<0.01) compared with nontumor regions (n=9), but there were no significant differences in CST1 expression between recurrent and nonrecurrent tumors or between stage I and II tumors (data not shown). Here, CST1 is linked to colorectal carcinoma.