CST3 is associated with tumor metastasis and invasion,23, 24 and its expression is correlated with a high risk of death in patients with colorectal cancer (CRC).25 CST6 is more highly expressed in metastatic cancers than in primary cancers,26, 27 and CST7 is upregulated in murine liver metastatic cancers. This evidence concerns the gene CST6 and metastatic malignant neoplasm.