ANO6 and Scott syndrome: Ano6 (gene TMEM16F) is a key regulator of calcium-dependent PS exposure.3 Loss-of-function mutations in TMEM16F have been identified in two Scott syndrome patients,3, 4 who have defective calcium-dependent PS exposure in platelets, erythrocytes and B lymphocytes.5 However, how Ano6 contributes to PS scrambling is not clear.6 Several groups have shown that Ano6 acts as a Cl− channel regulated by Ca2+ or cell volume.7, 8, 9, 10 However, it is not immediately clear how PS exposure could be directly regulated by Cl− conductance.