In complex on-going systemic response to sepsis, the cellular events instigated by A2MG ultimately lead to efficient disposal of the invading pathogen, upregulation of immunoresolving lipid mediators (e.g. RvD1, and RvD2) as well as immunomodulatory cytokines (e.g. IL-5 and IFN-γ), resulting in significant protection from death in experimental sepsis. The gene discussed is IFNG; the disease is Sepsis.