This response is hampered in sepsis where endotoxin upregulates G-protein-coupled receptor kinase 2 (GRK2) reducing cell surface expression of chemotactic receptors on the neutrophil plasma membrane (Alves-Filho et al, 2009) resulting in inefficient neutrophil activation and recruitment (Alves-Filho et al, 2009, 2010; Liu et al, 2012). The gene discussed is GRK2; the disease is Sepsis.