On the other hand, also for oncogenic gain of function (GOF) mutant p53 growing evidence supports a role in promoting cellular reprogramming and EMT and inciting expansion of mammary epithelial stem cells giving rise to mammary tumors (Sarig et al, 2010; Chang et al, 2011; Dong et al, 2013; Lu et al, 2013). This evidence concerns the gene TP53 and breast cancer.