This likely occurs in breast cancer, where NOTCH1 or FBXW7 manifest low mutational rates (Byrd et al, 2008; Mao et al, 2008; Ibusuki et al, 2011; Santarpia et al, 2012) and where, instead, high levels of Pin1 are frequent (Wulf et al, 2001; Girardini et al, 2011) and strongly correlate with activated N1-ICD. Here, NOTCH1 is linked to breast carcinoma.