Indeed, among Notch targets several are also Pin1 substrates (e.g. cyclin D1, NF-κB, Survivin) (Wulf et al, 2005; Cheng et al, 2013), suggesting that in addition to its role in sustaining Notch1 protein levels, Pin1 could promote breast cancer aggressiveness also by enhancing the activity of some Notch-induced Pin1 targets. The gene discussed is NOTCH1; the disease is breast cancer.