SPRY1 and neoplasm: Transfected cells were analyzed for the expression of genes known to regulate EC functions and vessel growth, such as transforming growth factor β receptor II (TGF-βRII), regulator of ERK activation Sprouty 1 (SPRY1), RhoGTPase RhoB and Sox7, and genes encoding regulators of cell migration such as vinculin. It has been previously shown that in human adipose tissue-derived mesenchymal stem cells miR-21 directly targets the 3′-UTR of TGF-βRII, thus inducing adipogenic differentiation (17) or inhibiting tumor angiogenesis induced by the cells (15).