MAPT and Cognitive impairment: Green tea and its polyphenolic ingredients EGCG have been suggested to possess neuroprotective effects in vitro [23–25], Lee et al. [25], Rezai-Zadeh et al. [26], and He et al. [27] reported that EGCG treatment significantly improved the cognitive deficits, APP processing, and Tau pathology in D-gal-induced AD mice, TgAPPsw line 2576 transgenic mice, and PS2 transgenic mice.