Alternatively, as RacGAP1 has been shown to recruit the RhoA GEF, Ect2, during cytokinesis 45 and at cell-cell junctions,46 and as RacGAP1 recruitment to IQGAP1 is required to induce RhoA activation in ovarian carcinoma cells,15 it is possible that IQGAP1-mediated regulation of RhoA occurs via the indirect recruitment of Ect2. Here, ECT2 is linked to ovarian carcinoma.