DDX41 and Hashimoto thyroiditis: Out of the 66 TS patients, 26 had thyroid autoimmune disorders (39.4%) (Table 1), 14 patients had Hashimoto’s thyroiditis with clinical or subclinical hypothyroidism (21.2%) and 12 patients had circulating anti-thyroid Abs, echographic pattern of diffuse hypoechogenicity and normal thyroid hormone levels (18.2%).