PDPN and neoplasm: Patients in the PDPN+ group had more frequent lymphatic invasion (P = 0.0461), vascular invasion (P = 0.0101), tumor size ≥3 cm (P = 0.0038), G3 grade tumor (P = 0.0344), and Union for International Cancer Control (UICC) grade pT3 or higher (P = 0.029) than patients in the PDPN– group (Table 1).