Contrary to its inhibitory effect on EGFR activation and activity in non-invasive tumor cells that either lack, or express low levels of AnxA6 [19,22], we hypothesized that in AnxA6-expressing invasive tumor cells AnxA6 may promote a sustained cell-surface expression of activated EGFR and therefore, persistent receptor activity that drives cell migration. This evidence concerns the gene ANXA6 and neoplasm.