As shown in Figure 4, in the presence of OVA-specific CD8+ T cells, OT-1 cells, luciferase-expressing MOVCAR incubated with NKG2D-Fc-RO had the greatest amount of OVA-specific CTL-mediated tumor cell death, as measured by a significant reduction in luminescence activity among different experimental groups. The gene discussed is CALR; the disease is neoplasm.