Activated neutrophils produce a large number of proinflammatory cytokines, such as tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-1β (Guerne et al. 1989; Terkeltaub et al. 1991; Choi et al. 2005c), all of which are involved in the pathogenesis and development of acute inflammation of gouty arthritis (Di Giovine et al. 1987). The gene discussed is TNF; the disease is gout.