Several studies reported Japanese individuals carrying T allele had greater mRNA level of ABCB1 and lower serum concentration of digoxin.27-30 Moreover, Siegmund et al. did not found any influence of ABCB1 3435C>T polymorphism on intestinal expression of P-gp and disposition of P-gp substrate talinolol in Caucasian.31 Several studies reported ABCB1 3435C>T polymorphism did not correlate with the expression and function of P-gp in acute myeloid leukemia, recipients of living-donor liver transplantation, peripheral blood lymphocyte and hematopoietic stem cells.32-35. Here, PGP is linked to acute myeloid leukemia.