Recent studies indicated that genetic polymorphism in GSTP1 and GSTM1 genes play a role in the efficacy of detoxifying cytotoxins generated by chemotherapeutics, including cisplatin and platinum agents, such as adriamycin, methotrexate, cisplatin and vincristine.9-13 Our study indicated that GSTP1 Ile105Val polymorphism may influence the chemotherapy efficacy in patients with osteosarcoma, and individuals with GSTP1 GG genotype had poor response to chemotherapy and a shorter survival time. The gene discussed is GSTP1; the disease is osteosarcoma.