Numbers of published studies have focused on GSTM1, GSTTI and GSTP1 genetic variation with respect to various cancers, but the role of GSTM1, GSTTI and GSTP1 genetic variation in osteosarcoma survival only discussed in a study conducted in China.8 Therefore, we conducted a comprehensive study to investigate the role of GSTM1, GSTTI and GSTP1 genetic variation involved in transport pathways in response to chemotherapy and clinical outcome of osteosarcoma. This evidence concerns the gene GSTM1 and cancer.