Previous studies have reported that polymorphism of IL-16 rs11556218 and rs8034928 T/C are associated with various human cancers, such as allergic contact dermatitis, systemic lupus erythematosus, nasopharyngeal carcinoma and renal cell carcinoma.6-8,13 Previous two studies have shown that polymorphisms of IL-16 rs11556218 and rs8034928 are associated with risk of CAD.14,15. The gene discussed is IL16; the disease is systemic lupus erythematosus.