A recent study has shown that intronic sequences encode microRNAs, which are associated with RNA-mediated gene silencing.16 This study has shown that IL-16 rs8034928 T/C polymorphism is in linkage disequilibrium with other casual genetic variants.16 In our study, we found that IL-16 rs8034928 T/C polymorphism could influence the risk of CAD. Here, IL16 is linked to coronary artery disorder.