It is an endothelial cell-specific mitogen which induces angiogenesis and increase vascular permeability by affecting endothelial tight-junction protein.6 In ocular vascular disease such as DME, VEGF levels has been found considerably higher in macular region.7 The Early Treatment Diabetic Retinopathy (ETDRS) shows 3-year risk of moderate visual loss due to macular edema was 32%, and focal macular laser photocoagulation was effective in the treatment of DME. Here, VEGFA is linked to macular retinal edema.