VEGFA and proliferative diabetic retinopathy: Recently off label use of IVB injection has been presented in small cohorts of patients with macular edema from various causes like CRVO13, AMD14 and Proliferative Diabetic Retinopathy (PDR).17 As VEGF disrupts the inner blood-retinal barrier and causes exravasation of fluids by affecting endothelial tight junctions.