Increase in the lipid peroxide compounds and reduction in SOD activity and GSH in diabetic mice retina have been displayed.21 Hartnett et al determined increase in the markers of oxidative stress and decrease in the antioxidant enzyme levels in subjects with diabetic retinopathy.22 The mechanism of reduction in retinal GSH determined in DM has not been clarified yet. Here, SOD1 is linked to diabetic retinopathy.