IL1B and major depressive disorder: Similar results have also been demonstrated with studies involved Fluoxetine39 as well as Paroxetine and Sertraline.40 In a meta-analysis of human studies where cytokine levels were measured in patients of major depression before and after treatment with anti-depressants, it was demonstrated that IL-1β and possibly IL-6 levels were reduced, adding to the evidence regarding anti-inflammatory effects of anti-depressants.41