There are several studies that investigated AMACR expression patterns in the literature.19,21-23 AMACR is a valuable diagnostic marker because of its persistent and strong expression in case of needle biopsies when the tissue is limited.18 In a study conducted by Sreekumar et al. they have found that PSA was non-specific and all men showed immun response to PSA free from cancer. The gene discussed is AMACR; the disease is cancer.