Many studies have demonstrated over activity of RAS in patients with metabolic syndrome, which are implicated in the occurrence of this syndrome.11-13 Studies support the presence of a local RAS in the adipose tissue, which may have an important role in the physiological regulation of this tissue and may have also a role in the pathophysiology of obesity and of obesity-related hypertension.14 Weisinger et al.15 reported that the RAS is functional within adipose tissue and angiotensin II, the active component of RAS, has been implicated in adipose tissue hypertrophy and insulin resistance. The gene discussed is AGT; the disease is obesity due to melanocortin 4 receptor deficiency.