AGT and obesity due to melanocortin 4 receptor deficiency: It was found that adipose tissue synthesizes and secretes the major components of RAS.19 There is also evidence for over activation of adipose tissue RAS in obesity in rodents,20 and for a positive correlation between adipose tissue angiotensinogen levels and BMI in humans.21 Moreover, circulating levels of angiotensinogen correlate with BMI and estimated total adipose tissue-derived angiotensinogen in humans,22 suggesting an endocrine role for adipose angiotensinogen.