As both serum IGF-1 and amino acids levels are important regulators of mTORC1 activity, we were interested in determining whether or not a reduction in protein intake down-regulates the mTOR signaling pathway in the LuCaP23.1-CR model, and whether or not the diet-induced inhibitory effect on tumor growth was dependent on mTOR inhibition. Here, IGF1 is linked to neoplasm.